The nuclease aisle

One of the themes that keeps popping up here is that of nucleases.  I thought I would post an adaptation of a table from a recent review by Ciarán Condon that lists the various ribonucleases in E. coli and B. subtilis.  The point is to illustrate the variety of nucleases that exist in bacteria, and to get readers to think more of the importance of RNA processing and, moreso, RNA turnover.

This table is adapted from Condon C (2007), Maturation and degradation of RNA in bacteria, Current Opinion in Microbiology 10: 271–278.  Enjoy.

enzyme E. coli B. subtilis endo/exo
PNPase pnp pnpA exo
RNase R rnr rnr exo
RNase PH rph rph exo
YhaM yhaM exo
RNase II rnb exo
RNAse D rnd exo
Oligo-RNase orn exo
RNase T rnt exo
RNase III rnc rncS endo
RNase P rnpAB rnpAB endo
RNase Z rbn mz endo
MazF/EndoA mazF ndoA endo
ChpBK chpBK endo
YoeB yoeB endo
RNase E rne endo
RNase G cafA endo
RNase I rna endo
RNase HI rnhA endo
RNase HII rnhB rnhB endo
RNase HIII rnhC endo
RNase M5 rnmV endo
RNase Bsn yurI endo
YhcR yhcR endo
RNase J1 rnjA exo+endo
RNase J2 rnjB exo+endo

In this table, “exo” = exonuclease and “endo”=endonuclease.  Also, cells filled with “-” indicate that the corresponding enzyme is apparently absent from the genome. It is fascinating to see the diversity of nucleases, and the variability in terms of the nuclease “contents” of genomes, even with just these two species.

Hopefully, some of these names ring bells in the minds of readers. I’ve mentioned a few of these in other essays, and some of the others (RNase P, RNase H) may be familiar.

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